Diabetes can be a debilitating disease. In both Type 1 and Type 2 diabetes, blood sugar levels rise dangerously high. Tissue damage can occur when sugar molecules bind to proteins in a glycation/oxidation process (called 'AGES'). This is a major pathway of vascular and neuronal damage in diabetes. In Type 1, the diabetic doesn't produce insulin, whereas in Type 2, they usually produce it, but have lost sensitivity to it. Lowering blood sugar, and preventing this glycation/oxidation reaction, is an important goal of the diabetic. Proper diet and exercise have been proven to be helpful for diabetes.
Nutritional formulas, in the way of vitamins, minerals, and herbs, can be utilized to help support this condition. One of the most promising support ingredients to appear in a long time is benfotiamine. Benfotiamine is a new, highly soluble a derivative of thiamine (vitamin B-1) with higher bioavailability. It has been proposed that, 'The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications.'Ingredients in Complete Gluco-D:
Benfotiamine: Exciting research on a new form of an old nutrient (vitamin B-1) has been putting benfotiamine in the spotlight. There are three major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage : 1. The advanced glycation end product (AGE) formation pathway, 2. The hexosamine pathway and 3. The diacylglycerol (DAG)-protein kinase C (PKC) pathway. They are all activated by increased availability of sugar metabolites. Researchers have now discovered that, 'the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways by activating the pentose phosphate pathway enzyme transketolase. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and also prevented experimental diabetic retinopathy.' Why is it important to think of benfotiamine and not just thiamine? In a rat study, nerve conduction velocity was nearly normalized after six months of benfotiamine application but not with thiamine. 'Furthermore, benfotiamine induced a major inhibition of neural imidazole-type AGE formation and completely prevented diabetes induced glycoxidation products (cmL)... Unlike treatment with water-soluble thiamine, timely administration of liposoluble benfotiamine was effective in the prevention of functional damage and of AGE and cmL formation in nerves of diabetic rats.'
Other supportive ingredients include: Bitter Melon, fenugreek, Siberian ginseng, Panax ginseng, chromium, zinc, acetyl-L-carnitine, gymnema sylvestre, and many other synergistics nutrients that make this product a super-charged formula! Complete Gluco-D Each tablet contains:Benfotiamine 35mg, Alpha Lipoic Acid 2.5 mg, Niacin 10mg, Vitamin B-1 15mg, Acetyl L-Carnitine 10mg, Pantothenic Acid 30mg, Quercetin 5mg, Inositol 25mg, Vitamin B-6 15mg, Methylcobalamin 100 mcg, Bitter Melon 25mg, Gymnema Sylvestre 60mg, Panax Ginseng 20mg, Niacinamide 20mg, Fenugreek 15mg, Siberian Ginseng 30mg, Biotin 30mcg,Co Enzyme Q-10 2.5mg, L-Taurine 30mg, L-Glutamine 30mg, Folic Acid 100 mcg, Protease (Vegetable source) 5 mg, Lipase (Veg Source) 5 mg, Amylase (veg Source) 5 mg, Vanadyl Sulfate 50 mcg, Chromium Chelate 50 mcg, Selenium Chelate 20mcg, Zinc Chelate 1.5mg, Magnesium Malate 1.6 mg, Manganese Chelate 500 mcg, Potassium Chelate 3mg, Contraindications: Contraindicated in hypoglycemia (low blood sugar), pregnancy, and with other diabetic drugs (i.e. glipizide). Fenugreek and ginseng are utilized in synergistic amounts to enhance this formula.
1. Hammes HP, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003 Mar;9(3):294-9.
2. Stracke H, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes. 2001;109(6):330-6.Size: 90 tablets